He was born on January 26, 1958 in Sacramento, California, the third of four children of Manuel Becerra, a construction and road worker who grew up in Tijuana, and Maria Teresa Becerra, a clerk and secretary who grew up in Guadalajara, and he was the first in his family to earn a four-year college degree. He graduated from C.K. McClatchy High School, earned a B.A. in economics from Stanford in 1980 and a J.D. from Stanford Law in 1984, and he is married to Dr. Carolina Reyes, an OB-GYN trained at Stanford and Harvard Medical, with whom he has three daughters, Clarisa, Olivia, and Natalia.
He started his public career as Deputy Attorney General of California under AG John Van de Kamp from 1987 to 1990, and he was elected to the California State Assembly for the 59th District in 1990, where he served a single term from 1991 to 1992. In 1992 he won a U.S. House seat, where he went on to serve 24 years across 12 consecutive terms from 1993 to 2017, representing the CA-30, CA-31, and CA-34 districts of Los Angeles, and in 1997 he joined the powerful Ways and Means Committee, becoming the first Latino to serve on it. He served as Vice Chair of the House Democratic Caucus from 2009 to 2013 and then as Chair from 2013 to 2017, becoming the second Hispanic American to lead the caucus.
In January 2017, Governor Jerry Brown appointed him to fill the seat of California Attorney General when Kamala Harris was elected to the U.S. Senate, and he was then elected to a full term in November 2018. As AG, his office filed 122 lawsuits against the first Trump administration over four years, including nine lawsuits on January 19, 2021, which was Trump's last day in office, and he defended AB 5, the gig worker classification law, against industry challenges before he left the office in March 2021.
On March 18, 2021, the U.S. Senate confirmed him as Secretary of Health and Human Services by a vote of 50 to 49, with Susan Collins of Maine the only Republican to vote yes, and he took office on March 19, 2021 and served until January 20, 2025, becoming the first Latino Secretary of HHS and the 25th Secretary overall. While he was there he led the implementation of the Inflation Reduction Act's drug price negotiation authority, and he announced his run for governor on April 2, 2025, framing his run as a fight to reclaim a California Dream he says is "slipping away."
